## Abstract Inactivating mutations in __APC__ are thought to be early, initiating events in colorectal carcinogenesis. To gain insight into the relationship between diet and inactivating __APC__ mutations, we evaluated associations between dietary factors and the occurrence of these mutations in a
✦ LIBER ✦
Multiple APC mutations in sporadic flat colorectal adenomas
✍ Scribed by van Wyk, René; Slezak, Premysl; Kotze, Maritha J; Jaramillo, Edgar; Koizumi, Koichi; Grobbelaar, Johanna J
- Book ID
- 110024886
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 222 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1018-4813
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The majority of colorectal cancers develop from adenomatous polyps under the influence of factors that are still poorly understood. Tumourigenesis is generally considered a multistep process in which multiple genetic alterations occur, eventually reflected in abnormalities of the cellular DNA conten