APC Mutations in Sporadic Medulloblastomas
β Scribed by Huatao Huang; Betania M. Mahler-Araujo; Anna Sankila; Leila Chimelli; Yasuhiro Yonekawa; Paul Kleihues; Hiroko Ohgaki
- Book ID
- 117022360
- Publisher
- American Society for Investigative Pathology
- Year
- 2000
- Tongue
- English
- Weight
- 163 KB
- Volume
- 156
- Category
- Article
- ISSN
- 0002-9440
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## BACKGROUND Medulloblastoma is a malignant, invasive embryonic tumor of the cerebellum. Sonic hedgehog (__SHH__) is a secreted glycoprotein that has a major role in the developing cerebellum. Activation of the __SHH__ pathway resulting from mutations in the __PATCH__ gene, which is a
## Abstract Inactivating mutations in __APC__ are thought to be early, initiating events in colorectal carcinogenesis. To gain insight into the relationship between diet and inactivating __APC__ mutations, we evaluated associations between dietary factors and the occurrence of these mutations in a