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Multiple abnormalities in immunoregulatory function of synovial compartment T cells in patients with rheumatoid arthritis

✍ Scribed by P. L. Romain; G. R. Burmester; R. W. Enlow; R. J. Winchester


Publisher
Springer
Year
1982
Tongue
English
Weight
734 KB
Volume
2
Category
Article
ISSN
0172-8172

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## Abstract Markedly elevated levels of T cells expressing Ia antigens were found in the synovial membranes and synovial fluids of patients with rheumatoid arthritis. The primary increase in expression of the la antigens was on the OKT 8+ (suppressor/cytotoxic) T cell subset. In addition, the total

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Rheumatoid arthritis is a T cell-mediated autoimmune disease. The lack of knowledge of the involved target antigens severely hampers research on relevant T cells in patients. Here we describe the functional analysis of freshly isolated T cells from the peripheral blood and the site of the lesion (sy