𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Multi-site neural tube closure in humans and maternal folate supplementation

✍ Scribed by Seller, Mary J.

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
322 KB
Volume
58
Category
Article
ISSN
0148-7299

No coin nor oath required. For personal study only.

✦ Synopsis

A group of 13 individuals with neural tube defects (NTD) despite maternal periconceptional folate supplementation was examined to determine precisely which closure sites along the neural tube had failed during embryogenesis. All the common forms of NTD, and thus all the usual closure sites, were represented. This suggests that folate deficiency does not act specifically on one region of the neural tube; rather, it may be more generally involved in the cause of human NTD. @ 1995 Wiley-Liss, Inc.

πŸ“œ SIMILAR VOLUMES

Epidemiological analysis of multi-site c
Epidemiological analysis of multi-site closure failure of neural tube in humans
✍ MartΓ­nez-FrΓ­as, MarΓ­a-Luisa; Urioste, Miguel; Bermejo, Eva; SanchΓ­s, Amparo; Rod πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 456 KB πŸ‘ 2 views

Van Allen et a l . [Am J Med Genet 47:723-743, 19931 proposed that there is multi-site initiation of neural tube closure in humans, and that neural tube defects (NTD) represent the failure of one or more of 5 closure sites. W e have studied from an epidemiologic perspective 774 liveborn infants with

Folic acid, methylation and neural tube
Folic acid, methylation and neural tube closure in humans
✍ Henk J. Blom πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 162 KB πŸ‘ 1 views

## Abstract This review provides a brief description of folate use and folic acid metabolism in relation to neural tube defect (NTD) risk. First, a meta‐analysis of reduction in NTD recurrence and occurrence risk with periconceptional folic acid supplementation is presented. Second, an overview of

Apparent lability of neural tube closure
Apparent lability of neural tube closure in laboratory animals and humans
✍ DeSesso, John M.; Scialli, Anthony R.; Holson, Joseph F. πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 154 KB πŸ‘ 2 views

Neural tube defects (NTDs), a set of structural abnormalities affecting the brain, spinal cord, and the skeletal and connective tissues that protect them, are common malformations among humans and laboratory animals. The embryogenesis of the neural tube is presented to convey the complexity of the p

Mouse mutants with neural tube closure d
Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects
✍ Muriel J. Harris; Diana M. Juriloff πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 236 KB πŸ‘ 1 views

## Abstract **BACKGROUND**: The number of mouse mutants and strains with neural tube closure defects (NTDs) now exceeds 190, including 155 involving known genes, 33 with unidentified genes, and eight β€œmultifactorial” strains. **METHODS**: The emerging patterns of mouse NTDs are considered in relati

Anencephaly and faciocranioschisis: Evid
Anencephaly and faciocranioschisis: Evidence of complete failure of closure 3 of the neural tube in humans
✍ Urioste, Miguel; Rosa, Alejandro πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 13 KB πŸ‘ 2 views

We report on a patient with median cleft of face and anencephaly as apparent consequence of delayed closure of the most rostral end of the neural tube. No other structural anomalies were found. To our knowledge, this child represents the first description of an isolated and complete failure of closu