Van Allen et a l . [Am J Med Genet 47:723-743, 19931 proposed that there is multi-site initiation of neural tube closure in humans, and that neural tube defects (NTD) represent the failure of one or more of 5 closure sites. W e have studied from an epidemiologic perspective 774 liveborn infants with
Anencephaly and faciocranioschisis: Evidence of complete failure of closure 3 of the neural tube in humans
β Scribed by Urioste, Miguel; Rosa, Alejandro
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 13 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0148-7299
No coin nor oath required. For personal study only.
β¦ Synopsis
We report on a patient with median cleft of face and anencephaly as apparent consequence of delayed closure of the most rostral end of the neural tube. No other structural anomalies were found. To our knowledge, this child represents the first description of an isolated and complete failure of closure 3 of the neural tube and supports the hypothesis of a multi-site model of neural tube closure in humans.
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Neural tube defects (NTDs), a set of structural abnormalities affecting the brain, spinal cord, and the skeletal and connective tissues that protect them, are common malformations among humans and laboratory animals. The embryogenesis of the neural tube is presented to convey the complexity of the p
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