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Epidemiological analysis of multi-site closure failure of neural tube in humans

✍ Scribed by Martínez-Frías, María-Luisa; Urioste, Miguel; Bermejo, Eva; Sanchís, Amparo; Rodríguez-Pinilla, Elvira

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
456 KB
Volume
66
Category
Article
ISSN
0148-7299

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✦ Synopsis

Van Allen et a l . [Am J Med Genet 47:723-743, 19931 proposed that there is multi-site initiation of neural tube closure in humans, and that neural tube defects (NTD) represent the failure of one or more of 5 closure sites. W e have studied from an epidemiologic perspective 774 liveborn infants with NTD by site of lesion following the multi-site classification proposed by Van Allen et al. [19931. As predicted by these authors, we could classify all the cases with NTD by the multisite closure model. W e have also estimated the prevalence of each failure closure site. This analysis indicates that not all the sites are affected with similar frequency.

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