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Multi-enzymatic syntheses of 11C-labelled L-tyrosine, L-DOPA, L-tryptophan and :-5-hydroxytryptophan

✍ Scribed by P. Bjurling; Y. Watanabe; P. Malmborg; B. Långström


Publisher
Elsevier Science
Year
1988
Weight
80 KB
Volume
39
Category
Article
ISSN
0883-2889

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📜 SIMILAR VOLUMES


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The aromatic amino acids tyrosine (TYR), 3,4-dihydroxyphenylalanine (DOPA) , tryptophan (TRP) and 5-hydroxytryptophan (5-HTP) are of especial interest because of their role as precursors for the neurotransmitters dopamine and serotonin, Scheme 1.

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## Abstract The application of HPLC for the purpose of separation of some amino acid racemates with aromatic substituents is described. Using simple untreated cellulose with an average particle size of 7 μm as stationary phase, complete resolution of D,L‐tryptophane and D,L‐5‐hydroxytryptophane ca

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## Abstract The synthesis of selectively ^14^C‐labeled l‐tryptophan and its derivative 5‐hydroxy‐l‐tryptophan using chemical and multienzymatic methods is reported. The mixture containing [1‐^14^C[‐dl‐alanine, indole or 5‐hydroxyindole has been converted to [1‐^14^C]‐l‐tryptophan or 5′‐hydroxy‐[1‐^