Matrix metalloproteinase-type 2 (MMP-2) degrades extracellular matrix, mediates cell migration and tissue remodeling, and is implicated in mediating neural crest (NC) and cardiac development. However, there is little information regarding the expression and distribution of MMP-2 during cardiogenesis
MT2-MMP Expression During Early Avian Morphogenesis
β Scribed by Patterson, Rachel A.; Cavanaugh, Ann M.; Cantemir, Veronica; Brauer, Philip R.; Reedy, Mark V.
- Book ID
- 118752578
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2012
- Tongue
- English
- Weight
- 778 KB
- Volume
- 296
- Category
- Article
- ISSN
- 1932-8486
- DOI
- 10.1002/ar.22618
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## Abstract Matrix metalloproteinases (MMPs) are zincβdependent proteases capable of degrading extracellular matrix components. The activity of these proteases is tightly regulated through the actions of the tissue inhibitors of metalloproteinases (TIMPs). Although the regulation of MMPs and TIMPs
## Membrane -type 1 matrix metalloproteinase (MT1-MMP) is a presumed activator of MMP2, which is one of the major proteinases in tumor cell invasion. In this study, we determined the clinico-pathologic significance of MT1-MMP expression in 68 human gastric carcinomas. The tumor-normal ratio (T/N r