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Mouse myocardial first-pass perfusion MR imaging

✍ Scribed by Bram F. Coolen; Rik P. M. Moonen; Leonie E. M. Paulis; Tessa Geelen; Klaas Nicolay; Gustav J. Strijkers

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
408 KB
Volume
64
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

A first‐pass myocardial perfusion sequence for mouse cardiac MRI is presented. A segmented ECG‐triggered acquisition combined with parallel imaging acceleration was used to capture the first pass of a Gd‐DTPA bolus through the mouse heart with a temporal resolution of 300–400 msec. The method was applied in healthy mice (N = 5) and in mice with permanent occlusion of the left coronary artery (N = 6). Baseline semiquantitative perfusion values of healthy myocardium showed excellent reproducibility. Infarct regions revealed a significant decrease in the semiquantitative myocardial perfusion values (0.05 ± 0.02) compared to remote myocardium (0.20 ± 0.04). Myocardial areas of decreased perfusion correlated well to infarct areas identified on the delayed‐enhancement scans. This protocol is a valuable addition to the mouse cardiac MRI toolbox for preclinical studies of ischemic heart disease. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.

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