Cancer, poliomyelitis, Alzheimer's and Gaucher disease, a seemingly disparate array of disorders, have become the target of powerful genetic analysis and drug screening protocols, using mouse strains that have been genetically altered to serve as models for understanding the disease and for helping
Mouse models of diseases of megakaryocyte and platelet homeostasis
โ Scribed by Catherine L. Carmichael; Warren S. Alexander
- Publisher
- Springer-Verlag
- Year
- 2011
- Tongue
- English
- Weight
- 307 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0938-8990
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The release of platelets into the circulation is preceded by considerable morphologic change of the parent megakaryocyte. The cell extends cytoplasmic processes into the venous sinusoids, which develop constrictions at intervals, revealing putative platelets. The pattern of cytoskeletal distribution
## Abstract The thrombocytopenia that follows infection of C3H/Bi mice with Friend leukemia virus (FV) has been investigated. At various times after infection, megakaryocytes in bone marrow and spleen were collected on Nuclepore filters, stained with the Feulgen procedure, and counted. At the same