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The importance of cytoskeleton proteins in megakaryocyte spreading and platelet formation

✍ Scribed by S. Baatout

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
349 KB
Volume
10
Category
Article
ISSN
0268-960X

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✦ Synopsis

The release of platelets into the circulation is preceded by considerable morphologic change of the parent megakaryocyte. The cell extends cytoplasmic processes into the venous sinusoids, which develop constrictions at intervals, revealing putative platelets. The pattern of cytoskeletal distribution changes during the spread of megakaryocytes in vitro. In this review, an attempt was made to summarize the data of the literature concerning the changes in the cytoskeletal pattern of megakaryocytes during their spreading and platelet formation.

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