✦ LIBER ✦

G proteins, phosphoinositides, and actin-cytoskeleton in the control of cancer growth

✍ Scribed by Maruta, Hiroshi; He, Hong; Tikoo, Anjali; Vuong, Thao; Nur-E-Kamal, MSA

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 149 KB
Volume: 47
Category: Article
ISSN: 1059-910X
DOI: 10.1002/(sici)1097-0029(19991001)47:1<61::aid-jemt6>3.0.co;2-y

No coin nor oath required. For personal study only.

✦ Synopsis

Almost three decades have passed since actin-cytoskeleton (acto-myosin complex) was first discovered in non-muscle cells. A combination of cell biology, biochemistry, and molecular biology has revealed the structure and function of many actin-binding proteins and their physiological role in the regulation of cell motility, shape, growth, and malignant transformation. As molecular oncologists, we would like to review how the function of actin-cytoskeleton is regulated through Ras/Rho family GTPases-or phosphoinosites-mediated signaling pathways, and how malignant transformation is controlled by actin/phosphoinositides-binding proteins or drugs that block Rho/Rac/CDC42 GTPases-mediated signaling pathways.

📜 SIMILAR VOLUMES

Interaction of AU-rich sequence binding

Interaction of AU-rich sequence binding proteins with actin: Possible involvement of the actin cytoskeleton in lymphokine mRNA turnover

✍ Tamás Henics; Eszter Nagy; Júlia Szekeres-Barthó 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 277 KB

In the current study, we report that cytochalasin-induced disruption of microfilaments stabilizes lymphokine mRNAs in activated human peripheral blood lymphocytes. Parallel with this, a dose-and time-dependent increase in AU-rich sequence binding protein (AUPB) activities is apparent in the nonionic

The clutch hypothesis revisited: Ascribi

The clutch hypothesis revisited: Ascribing the roles of actin-associated proteins in filopodial protrusion in the nerve growth cone

✍ Jay, Daniel G. 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 94 KB 👁 1 views

Cytoskeleton regulates expression of gen

Cytoskeleton regulates expression of genes for transforming growth factor-β1 and extracellular matrix proteins in dermal fibroblasts

✍ M. Varedi; A. Ghahary; P. G. Scott; E. E. Tredget 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 215 KB 👁 1 views

Cytoskeleton not only controls cell morphology but also regulates cell growth, migration, differentiation, and gene expression, events which are fundamental to embryogenesis, carcinogenesis, and wound healing. We have recently reported that reorganization of cytoskeleton induces expression of mRNA f

The expression of insulin-like growth fa

The expression of insulin-like growth factor and its binding protein mRNA in the endometrium of postmenopausal patients with breast cancer receiving tamoxifen

✍ Timo J. Laatikainen; Eija I. Tomás; Raimo J. Voutilainen 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 482 KB 👁 2 views

Differential insulin-like growth factor

Differential insulin-like growth factor (IGF)-independent interactions of IGF binding protein-3 and IGF binding protein-5 on apoptosis in human breast cancer cells. Involvement of the mitochondria.

✍ C. M. Perks; C. McCaig; J. M. P. Holly 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 324 KB 👁 2 views

A possible link between the pubertal gro

A possible link between the pubertal growth of girls and ovarian cancer in their daughters

✍ David J. P. Barker; Clive Osmond; Kent L. Thornburg; Eero Kajantie; Johan G. Eri 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 71 KB 👁 1 views