✦ LIBER ✦

Motor neuron disease and trace element toxicity

✍ Scribed by Michael J. Strong; Beiping He

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 40 KB
Volume: 13
Category: Article
ISSN: 0896-548X
DOI: 10.1002/(sici)1520-670x(2000)13:1<131::aid-jtra14>3.0.co;2-e

No coin nor oath required. For personal study only.

✦ Synopsis

There is a significant degree of overlap between the clinical syndromes of amyotrophic lateral sclerosis (ALS) and chronic AlCl 3 neurotoxicity. Although there is little, if any, significant overlap with acute AlCl 3 neurotoxicity, these latter studies are of importance in demonstrating that an exogenously administered neurotoxin can induce a posttranslational modification in neurofilament, sufficient to bring about neurofilamentous inclusions. The value in the study of chronic AlCl 3 neurotoxicity is in the recapitulation of neuronal damage resembling that of ALS and the observations that suggest that the potential for recovery from the neuronal injury can be mediated by microglia. Studies are currently in progress to further define this potential.

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