✦ LIBER ✦

Motor nerve biopsy studies in motor neuropathy and motor neuron disease

✍ Scribed by Massimo Corbo; M. Kamel Abouzahr; Norman Latov; Sandro Iannaccone; Angelo Quattrini; Raffaello Nemni; Nicola Canal; Arthur P. Hays

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 417 KB
Volume: 20
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199701)20:1<15::aid-mus2>3.0.co;2-k

No coin nor oath required. For personal study only.

✦ Synopsis

The clinical presentation of motor neuropathy often resembles that of motor neuron disease, sometimes leading to an erroneous diagnosis. Moreover, the underlying pathological process in motor neuropathy has been rarely investigated and there are no systematic studies of the affected motor nerves. We describe a new motor nerve biopsy procedure, performed in 15 patients: 6 with motor neuropathy and 9 with motor neuron disease. The motor branch from the anterior division of the obturator nerve to the gracilis muscle in the thigh was biopsied. In both groups of patients the motor nerves exhibited depletion of myelinated nerve fibers. In motor neuropathy there was a significantly higher density of regenerative clusters of small myelinated fibers in comparison to motor nerves from patients with motor neuron disease. In addition, in 3 patients with motor neuropathy there was evidence for demyelination with thinly myelinated axons and small onion bulb formations. These pathological studies of motor nerve biopsies can help to differentiate motor neuropathy from motor neuron disease.

📜 SIMILAR VOLUMES

Motor neuron disease and malignancy

✍ David S. Younger 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 72 KB 👁 1 views

Motor neuron disease, lymphoproliferativ

Motor neuron disease, lymphoproliferative disease, and bone marrow biopsy

✍ Elan D. Louis; Ann E. Hanley; Thomas H. Brannagan; William Sherman; Peregrine Mu 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 425 KB 👁 1 views

Some have suggested that nonfamilial motor neuron disease (MND) may be autoimmune, and the neurological disorder may benefit from immunotherapy. There have been reports of over 30 cases of lymphoproliferative disease (lymphoma, multiple myeloma, Waldenstrom's macroglobulinemia) with MND, and these p

The reorganization of motor units in mot

The reorganization of motor units in motor neuron disease

✍ Prof Barbara Emeryk-Szajewska; Jerzy Kopeć; Anna Karwanska 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 355 KB 👁 2 views

We studied 78 patients with motor neuron disease (MND) using concentric needle electromyography. Analysis on weak and maximal effort was performed using our own, fully automated, computer method, EMG-LAB. In addition to the conventional parameters of single motor unit action potentials (MUAPs) and i

Motor neuron disease and trace element t

Motor neuron disease and trace element toxicity

✍ Michael J. Strong; Beiping He 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 40 KB

There is a significant degree of overlap between the clinical syndromes of amyotrophic lateral sclerosis (ALS) and chronic AlCl 3 neurotoxicity. Although there is little, if any, significant overlap with acute AlCl 3 neurotoxicity, these latter studies are of importance in demonstrating that an exog

Antibody panels in idiopathic polyneurop

Antibody panels in idiopathic polyneuropathy and motor neuron disease

✍ Gil I. Wolfe; Waleed H. El-Feky; Jonathan S. Katz; Wilson W. Bryan; Frank H. Wia 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 55 KB 👁 2 views

We prospectively evaluated patients with idiopathic polyneuropathy (PN) and motor neuron disease (MND) with commercial antibody (Ab) panels. Patients with sensorimotor PN received a ''sensorimotor neuropathy profile'' [3-sulfated glucuronyl paragloboside (SGPG)/myelinassociated glycoprotein (MAG), G

Motor neuron disease presenting as acute

Motor neuron disease presenting as acute respiratory failure: Electrophysiological studies

✍ Robert Chen; François Grand'maison; John D. Brown; Charles F. Bolton 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 174 KB 👁 1 views

4 cases examined at autopsy. 3 As the involvement is 15. Tandan R, Bradley WG: Amyotrophic lateral sclerosis: Part 1. severe and irreversible, these patients were likely to Clinical features, pathology and ethical issues in management.