✦ LIBER ✦

Lead and motor neuron disease

✍ Scribed by Roger M. Morrell

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 92 KB
Volume: 8
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410080118

No coin nor oath required. For personal study only.

✦ Synopsis

the most constant neuropathological changes in WHD. The degenerative process in these neurons is surprisingly identical to that affecting motor neurons or spinal ganglioncells in this disease. How can internally placed thalamic neurons, with their axons entirely buried in the cerebral hemispheres, be injured by nerve root traction [21 or be compressed by "glial bundles" [l]? Dr Chou's pioneer work kindled the scientific interest of neuropathologists in the "glial bundles," a newly recognized type of astocytic reaction just at the interface of the central and peripheral nervous systems. But any hypothesis concerning the pathogenesis of W H D should explain all aspects of this disease, which affects multiple heterogeneous structures in the central nervous system.

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