𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Morphological transformation of cells induced by Kirsten sarcoma virus transforming factor is independent of serine protease

✍ Scribed by R. Jerrold Fulton; Paul L. Kaplan; David A. Hart; Brad Ozanne

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
394 KB
Volume
110
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Reports from several laboratories have suggested that the virus transformed state may be maintained either by ectopically produced growth factors of alternatively by ectopically produced serine proteases including plasminogen activator. Here we show that the maintenance of transformation induced by Kirsten sarcoma virus induced growth factor(s) is independent of serine proteases in that (1) the factors are not themselves serine proteases, and (2) the growth factors do not induce the expression of detectable serine proteases or plasminogen activator.

📜 SIMILAR VOLUMES

Characterization of guinea-pig embryo ce
Characterization of guinea-pig embryo cells transformed by Kirsten mouse sarcoma virus
✍ Johng S. Rhim; Fuw G. Duh; Han Y. Cho; R. G. Huebner 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 French ⚖ 980 KB

## Abstract Guinea‐pig embryo cells were transformed in vitro by the Kirsten strain of mouse sarcoma virus (Ki‐MSV). The transformed cells were found to release infectious virus continuously and produced high titers of group‐specific, complement‐fixing antigen characteristic of the murine leukemia—

Chemical transformation of human reverta
Chemical transformation of human revertant cells induced by murine sarcoma virus
✍ Han Y. Cho; Paul Arnstein; Johng S. Rhim 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 515 KB

## Abstract A human revertant cell line, derived from non‐producer human osteosarcoma cells (NP/KHOS) induced by Kirsten murine sarcoma virus, was treated __in vitro__ with various levels of polycyclic aromatic hydrocarbons (3‐methylcholanthrene, 7,12‐dimethylbenz(__a__)anthracene, and benzo(__a__)

Properties of a sarcoma-growth-factor-li
Properties of a sarcoma-growth-factor-like peptide from cells transformed by a temperature-sensitive sarcoma virus
✍ Joseph E. De Larco; Yvette A. Preston; George J. Todaro 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 869 KB

## Abstract Serum‐free conditioned media was collected from three sarcoma virus‐transformed cell lines and an untransformed cell line. All three virally transformed lines produced and released growth factors into their serum‐free media. The major activity in all cases, whether the cells were transf

Transformation of single myeloid precurs
Transformation of single myeloid precursor cells by the malignant histiocytosis sarcoma virus (MHSV): Generation of growth-factor-independent myeloid colonies and permanent cell lines
✍ K. Klingler; G. R. Johnson; N. A. Nicola; G. Arman; N. Kluge; W. Ostertag 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 700 KB

Direct single-cell assays for oncogenic transformation are available for fibroblasts but not for other cell types. Using malignant histiocytosis sarcoma virus (MHSV), a member of t h e ras family of retroviruses, in vivo-infected granulocytehacrophage and macrophage precursor cells lost the requirem