Monoclonal, natural antibodies prevent development of diabetes in the non-obese diabetic (NOD) mouse
✍ Scribed by Andersson, Åsa; Forsgren, Stina; Söderström, Åsa; Holmberg, Dan
- Book ID
- 122915771
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 767 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0896-8411
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Diabetes prone NOD female mice were fed diets containing different proteins from just before weaning. Only mice receiving meat meal or casein as the protein source developed diabetes at the rate expected from this colony. Lactalbumin and gluten did not precipitate diabetes except in a small number.
Early intensive insulin treatment is thought to improve subsequent Beta-cell function in Type 1 (insulin-dependent) diabetic patients. Prophylactic insulin administration also reduced diabetes incidence in diabetes-prone animals. To study the mechanisms by which these effects occur, we tested the ab