The nonobese diabetic (NOD) mouse spontaneously develops an autoimmune diabetes that shares many immunogenetic features with human insulin-dependent diabetes mellitus (IDDM), type 1 diabetes. The mononuclear cell infiltrates in the islet, which results in the development of insulitis (a prerequisite
Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse
β Scribed by Helen E. Thomas; Thomas W. H. Kay
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 140 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1520-7552
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The development of diabetes in non-obese diabetic (NOD) mice, which normally takes between 3 and 7 months, can be accelerated by cyclophosphamide (CY) injections, with rapid progression to diabetes within only 2Β±3 weeks. This insulin-dependent diabetes mellitus (IDDM) can be prevented or delayed in
Background The non-obese diabetic (NOD) mouse is a widely used model of Type 1 diabetes mellitus (Type 1 DM), which displays many of the characteristics of the disease found in humans. Nicotinamide (NA) is currently being tested in large-scale, multi-centre human trials for the prevention of Type 1
The prognostic significance of islet cell specific autoantibodies at the diagnosis of Type 1 (insulin-dependent) diabetes mellitus for the persistence of residual beta-cell function over the first 2 years of clinical disease was evaluated in a prospective population-based study. Seven hundred and ei
Secondary failure of plasma glucose control following initial successful response to diet therapy may be due to dietary indiscretion, or to progression of the intrinsic diabetic condition. We report a 10-year prospective natural history study of 432 newly diagnosed diabetic patients aged 40-69 years