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Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and β-islet cells

✍ Scribed by Adelaida Sarukhan; Oskar Lechner; Harald von Boehmer


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
146 KB
Volume
29
Category
Article
ISSN
0014-2980

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The nonobese diabetic (NOD) mouse spontaneously develops an autoimmune diabetes that shares many immunogenetic features with human insulin-dependent diabetes mellitus (IDDM), type 1 diabetes. The mononuclear cell infiltrates in the islet, which results in the development of insulitis (a prerequisite