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Monoacetylcurcumin: A new inhibitor of eukaryotic DNA polymerase λ and a new ligand for inhibitor-affinity chromatography

✍ Scribed by Yoshiyuki Mizushina; Tomomi Ishidoh; Toshifumi Takeuchi; Noriko Shimazaki; Osamu Koiwai; Kouji Kuramochi; Susumu Kobayashi; Fumio Sugawara; Kengo Sakaguchi; Hiromi Yoshida

Book ID
116291600
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
168 KB
Volume
337
Category
Article
ISSN
0006-291X

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Using a new aldol approach, starting directly from the pyruvate enolate 7 and reacting it chelate controlled with the chiral a-aminoaldehyde s, the aldol adduct 2 is obtained diastereoselectively and is converted subsequently by 1,3-induced asymmetric hydrogenation into the chiral title compound 11.