✦ LIBER ✦
New diastereoselective synthesis of a novel chiral λ-(Aminoalkyl)-α-hydroxy-λ-lactones and their application for the synthesis of renin inhibitors
✍ Scribed by Rainer Metternich; Werner Lüdi
- Book ID
- 104216553
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 190 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Using a new aldol approach, starting directly from the pyruvate enolate 7 and reacting it chelate controlled with the chiral a-aminoaldehyde s, the aldol adduct 2 is obtained diastereoselectively and is converted subsequently by 1,3-induced asymmetric hydrogenation into the chiral title compound 11. This novel lactone is further used for the synthesis of potent renin inhibitors.