Mono- and Bivalent Ligands Bearing Mannose 6-Phosphate (M6P) Surrogates: Targeting the M6P/Insulin-Like Growth Factor II Receptor
β Scribed by Berkowitz, David B.; Maiti, Gourhari; Charette, Bradley D.; Dreis, Christine D.; MacDonald, Richard G.
- Book ID
- 126163210
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 174 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1523-7060
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M6P/IGF2R encodes a multifunctional protein involved in lysosomal enzyme trafficking, fetal organogenesis, tumor suppression, and cytotoxic T cell-induced apoptosis. M6P/IGF2R is imprinted and expressed only from the maternally inherited allele in marsupials and rodents. In contrast, humans were ini
The mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) suppresses cell growth through binding to the insulin-like growth factor 2 (IGF2) and latent complex of the transforming growth factor-β€ (TGF-β€). Recently, it was reported in the United States that loss of heterozygosity (LOH)