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The hepatocyte is a direct target for transforming-growth factor β activation via the insulin-like growth factor II/mannose 6-phosphate receptor

✍ Scribed by Laurence Villevalois-Cam; Claude Rescan; David Gilot; Frédéric Ezan; Pascal Loyer; Bernard Desbuquois; Christiane Guguen-Guillouzo; Georges Baffet


Book ID
118564859
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
415 KB
Volume
38
Category
Article
ISSN
0168-8278

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These studies investigate the role of transforming growth factor-61, a potent inhibitor of epithelial cell proliferation and stimulator of extracellular matrix biosynthesis, during intrahepatic bile duct hyperplasia and biliary fibrosis. These pathogenic responses were induced in rats by common bile