Molecular Targeting of Alzheimer's Amyloid Plaques for Contrast-Enhanced Magnetic Resonance Imaging
β Scribed by Joseph F. Poduslo; Thomas M. Wengenack; Geoffry L. Curran; Thomas Wisniewski; Einar M. Sigurdsson; Slobodon I. Macura; Bret J. Borowski; Clifford R. Jack Jr.
- Book ID
- 115641763
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 626 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0969-9961
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## Abstract One of the cardinal pathologic features of Alzheimer's disease (AD) is the formation of senile, or amyloid, plaques. Transgenic mice have been developed that express one or more of the genes responsible for familial AD in humans. Doubly transgenic mice develop βhumanβlikeβ plaques, prov
## Abstract We performed threeβdimensional, highβresolution magnetic resonance imaging (MRI) of fixed mouse brains to determine whether MRI can detect amyloid plaques in transgenic mouse models of Alzheimer's disease. Plaqueβlike structures in the cortex and hippocampus could be clearly identified