The genetic rescue of Pgdn lethal alleles, accomplished by combining them with mutations lacking glucose-6-phosphate dehydrogenase activity, has led to the hypothesis that Pgdn lethality may be due to the accumulation of 6-phosphogluconate. In this article we report the rescue of Pgdn/Y males by die
Molecular structure of a naturally occurring alcohol dehydrogenase null activity allele inDrosophila melanogaster
β Scribed by John B. Gibson; Ann Verona Wilks
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 526 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0006-2928
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Using a double mutant strain, Pgdn Zwn, we have developed an assay for 6-phosphogluconolactonase activity and have demonstrated its occurrence in adult Drosophila melanogaster.
We have examined the kinetic properties of enzymes produced by the electrophoretically fast (F) and slow (S) alleles at the alcohol dehydrogenase locus in a polymorphic laboratory population of Drosophila melanogaster. The product of the F allele has approximately twice the specific activity of the
Six naturally occurring but rare alleles of sn-glycerol-3-phosphate dehydrogenase (Gpdh) in Drosophila melanogaster have been investigated in this study. They all belong to a class of Gpdh tJF (ultra-fast) alleles, because their electrophoretic mobilities are faster than that of the Gpdh F (fast) al