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Dietary rescue of a lethal “null” activity allele of 6-phosphogluconate dehydrogenase inDrosophila melanogaster

✍ Scribed by M. Beatrice Hughes; John C. Lucchesi

Publisher: Springer
Year: 1978
Tongue: English
Weight: 353 KB
Volume: 16
Category: Article
ISSN: 0006-2928
DOI: 10.1007/bf00484212

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✦ Synopsis

The genetic rescue of Pgdn lethal alleles, accomplished by combining them with mutations lacking glucose-6-phosphate dehydrogenase activity, has led to the hypothesis that Pgdn lethality may be due to the accumulation of 6-phosphogluconate. In this article we report the rescue of Pgdn/Y males by dietary supplements (fructose and linolenate) designed to minimize 6-phosphogluconate production.

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