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Demonstration of 6-phosphogluconolactonase activity inDrosophila melanogasterusing a null allele of 6-phosphogluconate dehydrogenase

โœ Scribed by M. Beatrice Hughes; John C. Lucchesi


Publisher
Springer
Year
1978
Tongue
English
Weight
358 KB
Volume
16
Category
Article
ISSN
0006-2928

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โœฆ Synopsis


Using a double mutant strain, Pgdn Zwn, we have developed an assay for 6-phosphogluconolactonase activity and have demonstrated its occurrence in adult Drosophila melanogaster.


๐Ÿ“œ SIMILAR VOLUMES


Dietary rescue of a lethal โ€œnullโ€ activi
โœ M. Beatrice Hughes; John C. Lucchesi ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› Springer ๐ŸŒ English โš– 353 KB

The genetic rescue of Pgdn lethal alleles, accomplished by combining them with mutations lacking glucose-6-phosphate dehydrogenase activity, has led to the hypothesis that Pgdn lethality may be due to the accumulation of 6-phosphogluconate. In this article we report the rescue of Pgdn/Y males by die

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There are two structural forms of glucose 6-phosphate dehydrogenase activity in Drosophila melanogaster. Whether one or the other or both show in vitro (and probably in vivo) activity depends on the genotype of a sex-linked locus (Zw). In this article, the relative fittnesses of heterozygotes (with