The genetic rescue of Pgdn lethal alleles, accomplished by combining them with mutations lacking glucose-6-phosphate dehydrogenase activity, has led to the hypothesis that Pgdn lethality may be due to the accumulation of 6-phosphogluconate. In this article we report the rescue of Pgdn/Y males by die
โฆ LIBER โฆ
Demonstration of 6-phosphogluconolactonase activity inDrosophila melanogasterusing a null allele of 6-phosphogluconate dehydrogenase
โ Scribed by M. Beatrice Hughes; John C. Lucchesi
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 358 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0006-2928
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โฆ Synopsis
Using a double mutant strain, Pgdn Zwn, we have developed an assay for 6-phosphogluconolactonase activity and have demonstrated its occurrence in adult Drosophila melanogaster.
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There are two structural forms of glucose 6-phosphate dehydrogenase activity in Drosophila melanogaster. Whether one or the other or both show in vitro (and probably in vivo) activity depends on the genotype of a sex-linked locus (Zw). In this article, the relative fittnesses of heterozygotes (with