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Molecular structure of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea

โœ Scribed by Smith, H. Warren; Camerman, Arthur; Camerman, Norman


Book ID
115509147
Publisher
American Chemical Society
Year
1978
Tongue
English
Weight
489 KB
Volume
21
Category
Article
ISSN
0022-2623

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Gas-chromatographic determination of 1-(
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The reaction of 1-(2chloroethyl)-3-( t'rans-4-methylcyclohexyl)-1-nitrosourea (methyl-CCNU) with trifluoroacetic anhydride is reported. Gas-liquid chromatography of the resulting trifluoroacetyl derivative is applied to determine methyl-CCNU in plasma with a limit of detection of 1.5 pg ml-'.

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The physiologic disposition of radioactive-labelled CCNU and MeCCNU was studied in patients receiving these drugs as part of their early clinical trial. CCNU was given orally in doses of 30-100 mg/m2 a n d MeCCNU in doses of 120-290 mg/m?. With both drugs, significant plasma levels of radioactivity