Molecular structure of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea
โ Scribed by Smith, H. Warren; Camerman, Arthur; Camerman, Norman
- Book ID
- 115509147
- Publisher
- American Chemical Society
- Year
- 1978
- Tongue
- English
- Weight
- 489 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-2623
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๐ SIMILAR VOLUMES
The reaction of 1-(2chloroethyl)-3-( t'rans-4-methylcyclohexyl)-1-nitrosourea (methyl-CCNU) with trifluoroacetic anhydride is reported. Gas-liquid chromatography of the resulting trifluoroacetyl derivative is applied to determine methyl-CCNU in plasma with a limit of detection of 1.5 pg ml-'.
The physiologic disposition of radioactive-labelled CCNU and MeCCNU was studied in patients receiving these drugs as part of their early clinical trial. CCNU was given orally in doses of 30-100 mg/m2 a n d MeCCNU in doses of 120-290 mg/m?. With both drugs, significant plasma levels of radioactivity