Molecular regulation of kidney development: is the answer blowing in the Wnt?
β Scribed by Calli E. Merkel; Courtney M. Karner; Thomas J. Carroll
- Book ID
- 106160665
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 453 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0931-041X
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Members of the Wnt family of secreted glycoproteins act as short-range signaling molecules in vertebrate embryogenesis. Previous work has shown that Wnt-4 is required for kidney development. Mice lacking functional Wnt-4 fail to form pretubular cell aggregates. Wnt-4 acts as an autoinducer of the me
## Abstract Invasion of colorectal carcinomas (CC) is characterized by nuclear accumulation of Ξ²βcatenin, a key component of the Wnt pathway, in scattered tumor cells. Ξ²βcatenin acts in cooperation with Tβcell factor (Tcf) HMGβbox transcription factors as a transcriptional activator of genes involv