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Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

✍ Scribed by Stark, Kevin; Vainio, Seppo; Vassileva, Galya; McMahon, Andrew P.

Book ID
109790659
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
731 KB
Volume
372
Category
Article
ISSN
0028-0836

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Members of the Wnt family of secreted glycoproteins act as short-range signaling molecules in vertebrate embryogenesis. Previous work has shown that Wnt-4 is required for kidney development. Mice lacking functional Wnt-4 fail to form pretubular cell aggregates. Wnt-4 acts as an autoinducer of the me