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Molecular Recognition of Macrocyclic Peptidomimetic Inhibitors by HIV-1 Protease †,‡

✍ Scribed by Martin, Jennifer L.; Begun, Jake; Schindeler, Aaron; Wickramasinghe, Wasa A.; Alewood, Dianne; Alewood, Paul F.; Bergman, Douglas A.; Brinkworth, Ross I.; Abbenante, Giovanni; March, Darren R.; Reid, Robert C.; Fairlie, David P.

Book ID
127215610
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
403 KB
Volume
38
Category
Article
ISSN
0006-2960

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Structure-activity relationships for mac
Structure-activity relationships for macrocyclic peptidomimetic inhibitors of HIV-1 protease
✍ G. Abbenante; D.A. Bergman; R.I. Brinkworth; D.R. March; R.C. Reid; P.A. Hunt; I 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 261 KB

A series of appended macrocycles were synthesized and tested as inhibitors of HIV-1 protease (HIV PR). The macrocycle structurally mimics an N-terminal tripeptide component of peptide substrates. Structure-activity relationships explore steric limitations to the size and shape of the substituents an