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Design of small peptidomimetic HIV-1 protease inhibitors and prodrug forms

โœ Scribed by Yoshiaki Kiso; Hikaru Matsumoto; Satoshi Yamaguchi; Tooru Kimura

Book ID
110270726
Publisher
Springer Netherlands
Year
1999
Tongue
English
Weight
107 KB
Volume
6
Category
Article
ISSN
1573-3149

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โœ G. Abbenante; D.A. Bergman; R.I. Brinkworth; D.R. March; R.C. Reid; P.A. Hunt; I ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 261 KB

A series of appended macrocycles were synthesized and tested as inhibitors of HIV-1 protease (HIV PR). The macrocycle structurally mimics an N-terminal tripeptide component of peptide substrates. Structure-activity relationships explore steric limitations to the size and shape of the substituents an