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Molecular modeling studies of novel retro-binding tripeptide active-site inhibitors of thrombin

✍ Scribed by Wan F. Lau; Lydia Tabernero; John S. Sack; Edwin J. Iwanowicz


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
861 KB
Volume
3
Category
Article
ISSN
0968-0896

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A solid phase chemistry approach utilizing Mitsunobu chemistry, amine functionalization, and parallel purification was used to produce a diverse library of benzothiophene analogs. These analogs were used to advance the SAR of this class of molecules and give new directions for future studies.