Molecular medicine: predicting and preventing Huntington’s disease
✍ Scribed by Ferdinando Squitieri; Milena Cannella; Luigi Frati
- Book ID
- 106268552
- Publisher
- Springer Milan
- Year
- 2008
- Tongue
- English
- Weight
- 84 KB
- Volume
- 29
- Category
- Article
- ISSN
- 1590-1874
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Huntington's disease (HD) is a progressive neurodegenerative disease striking principally medium spiny GABAergic neurons of the caudate nucleus of the basal ganglia. It affects about one in 10,000 individuals and is transmitted in an autosomal dominant fashion. The molecular basis of the disease is
Polyglutamine expansions in huntingtin (Htt) are known to cause the profound neurodegenerative disorder, Huntington's disease (HD). Mitochondrial dysfunction has long been implicated in the pathophysiology of HD, but the underlying mechanism remains obscure. An article by Costa et al in this months
## Abstract Four Huntington's disease (HD) patients were treated with traditional Chinese medicines Yi‐Gan San (YGS) and Chaihu‐Jia‐Longgu‐Muli Tan (CLMT) in a cross‐over manner. Two patients took YGS for 8 weeks first, and after 4 weeks of washing out, they took CLMT for 8 weeks. Two other patient