Huntington's disease (HD) is a late-onset degenerative disorder of the central nervous system, caused by a dominantly inherited mutation in a gene on chromosome 4p. The identification of the trinucleotide repeat mutation responsible for this disorder has been an important step towards understanding
Prediction of Huntington's disease
β Scribed by C. D. Marchsden
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 228 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Huntington's disease (HD) is a progressive neurodegenerative disease striking principally medium spiny GABAergic neurons of the caudate nucleus of the basal ganglia. It affects about one in 10,000 individuals and is transmitted in an autosomal dominant fashion. The molecular basis of the disease is
jections 7 and single cell recording studies in putamen and pallidum of primates, 8 and also in humans during stereotaxic surgery. 9 Also, it is important in this differing topography that the changes in dopaminergic input into the striatum in Parkinson's disease affect the caudate and putamen in a