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Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases

โœ Scribed by Hadassa Waterman; Yosef Yarden

Book ID
117102701
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
347 KB
Volume
490
Category
Article
ISSN
0014-5793

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## Abstract Signaling by the Epidermal Growth Factor Receptor (EGFR) and related ErbB family receptor tyrosine kinases can be deregulated in human malignancies as the result of mutations in the genes that encode these receptors. The recent identification of EGFR mutations that correlate with sensit