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Receptor tyrosine kinases: mechanisms of activation and signaling

✍ Scribed by Stevan R Hubbard; W Todd Miller


Book ID
113524863
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
532 KB
Volume
19
Category
Article
ISSN
0955-0674

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## Abstract Signaling by the Epidermal Growth Factor Receptor (EGFR) and related ErbB family receptor tyrosine kinases can be deregulated in human malignancies as the result of mutations in the genes that encode these receptors. The recent identification of EGFR mutations that correlate with sensit