Restriction endonuclease mapping of chromosomal DNA has been used to determine whether the alpha-globin gene deletion or non-deletion form of alpha-thalassemia is the underlying molecular defect in individuals of two unrelated German families with alpha-thalassemia syndromes. The obtained DNA patter
MOLECULAR MECHANISMS IN α THALASSEMIA: RACIAL DIFFERENCES IN α-GLOBIN GENE ORGANIZATION
✍ Scribed by Stephen H. Embury; Andree M. Dozy; Yuet Wai Kan
- Book ID
- 118718575
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 967 KB
- Volume
- 344
- Category
- Article
- ISSN
- 0890-6564
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Analysis of alpha-thalassemia syndromes in several German families revealed DNA deletion as well as non-deletion forms as the molecular basis for the defects. Thus, the alpha-thalassemia haplotype was identified as the (-alpha)3.7 rightward deletion form, and the region of the putative recombination
Alpha-globin genes were analyzed by the direct method of DNA mapping using alpha- and zeta-globin specific probes in a Thai family in which the proposita was an unusually mild beta zero-thalassemia homozygote. alpha zero-Thalassemia was found to be segregating in the family, inherited from the propo