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Molecular mapping of a site for Cd2+-induced modification of human ether-à-go-go-related gene (hERG) channel activation

✍ Scribed by David Fernandez; Azad Ghanta; Krista I. Kinard; Michael C. Sanguinetti


Book ID
110113450
Publisher
Cambridge University Press
Year
2005
Tongue
English
Weight
517 KB
Volume
567
Category
Article
ISSN
0022-3751

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Effects of phosphodiesterase (PDE) inhib
✍ Kiyokazu Yunomae; Satoko Ichisaki; Junko Matsuo; Shinichi Nagayama; Koichiro Fuk 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 328 KB

## Abstract It is presumed that phosphodiesterase (PDE) inhibitors have two mechanisms for inhibition of hERG currents in the acute applications to cells: direct channel block, and downregulation of human ether‐a‐go‐go related gene (hERG) activities by PKA‐dependent pathway mediated phosphorylation