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Molecular basis of slow activation of the human ether-á-go-go related gene potassium channel

✍ Scribed by Rajesh N. Subbiah; Catherine E. Clarke; David J. Smith; JingTing Zhao; Terence J. Campbell; Jamie I. Vandenberg


Book ID
110112750
Publisher
Cambridge University Press
Year
2004
Tongue
English
Weight
339 KB
Volume
558
Category
Article
ISSN
0022-3751

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Effects of phosphodiesterase (PDE) inhib
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## Abstract It is presumed that phosphodiesterase (PDE) inhibitors have two mechanisms for inhibition of hERG currents in the acute applications to cells: direct channel block, and downregulation of human ether‐a‐go‐go related gene (hERG) activities by PKA‐dependent pathway mediated phosphorylation