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Molecular genetics of acute promyelocytic leukemia

✍ Scribed by Richard J Lin; David A Egan; Ronald M Evans


Book ID
114174227
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
268 KB
Volume
15
Category
Article
ISSN
0168-9525

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The molecular genetics of acute promyelo
✍ F. Grignani; M. Fagioli; P.F. Ferrucci; M. Alcalay; P.G. Pelicci πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 English βš– 952 KB

The chromosome breakpoints of the acute promyelocytic leukemia (APL)-specific 15;17 translocation have recently been isolated. They are localized on a previously unknown gene, PML, on chromosome 15 and in the gene that encodes the alpha retinoic acid receptor (RART) on 17. The translocation, which i