The molecular genetics of acute promyelo
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F. Grignani; M. Fagioli; P.F. Ferrucci; M. Alcalay; P.G. Pelicci
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Article
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1993
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Elsevier Science
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English
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The chromosome breakpoints of the acute promyelocytic leukemia (APL)-specific 15;17 translocation have recently been isolated. They are localized on a previously unknown gene, PML, on chromosome 15 and in the gene that encodes the alpha retinoic acid receptor (RART) on 17. The translocation, which i