The chromosome breakpoints of the acute promyelocytic leukemia (APL)-specific 15;17 translocation have recently been isolated. They are localized on a previously unknown gene, PML, on chromosome 15 and in the gene that encodes the alpha retinoic acid receptor (RART) on 17. The translocation, which i
In vivo analysis of the molecular genetics of acute promyelocytic leukemia
โ Scribed by Pandolfi, Pier Paolo
- Book ID
- 110064861
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 311 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0950-9232
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๐ SIMILAR VOLUMES
The primary cytogenetic abnormality in acute promyelocytic leukemia (APL; FAB M3) is a reciprocal translocation, t( 15; I7)(q22;q I2), which serves t o fuse the PML gene on chromosome I5 t o the retinoic acid receptor alpha (RAM) gene on chromosome 17. A PML-MM fusion message transcribed from the de
Acute Promyelocytic Leukemia (APL) is a distinct subtype of myeloid leukemia that in the USA alone affects more than 3,000 individuals every year. APL is characterized by three distinct and unique features: i) the accumulation in the bone marrow of tumor cells with promyelocytic features; ii) the in