In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications
โ Scribed by He, Li-Zhen; Merghoub, Taha; Pandolfi, Pier Paolo
- Book ID
- 110062464
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 953 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0950-9232
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Acute Promyelocytic Leukemia (APL) is a distinct subtype of myeloid leukemia that in the USA alone affects more than 3,000 individuals every year. APL is characterized by three distinct and unique features: i) the accumulation in the bone marrow of tumor cells with promyelocytic features; ii) the in
The primary cytogenetic abnormality in acute promyelocytic leukemia (APL; FAB M3) is a reciprocal translocation, t( 15; I7)(q22;q I2), which serves t o fuse the PML gene on chromosome I5 t o the retinoic acid receptor alpha (RAM) gene on chromosome 17. A PML-MM fusion message transcribed from the de