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Molecular signature of retinoic acid treatment in acute promyelocytic leukemia

✍ Scribed by Meani, Natalia; Minardi, Simone; Licciulli, Silvia; Gelmetti, Vania; Coco, Francesco Lo; Nervi, Clara; Pelicci, Pier Giuseppe; Müller, Heiko; Alcalay, Myriam

Book ID: 110069555
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 433 KB
Volume: 24
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1208498

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Acute promyelocytic leukemia is characterized by the reciprocal translocation of chromosomes 15 and 17. All-trans retinoic acid (ATRA) efficiently induces differentiation of the abnormal promyelocytes. In this study, we had used ATRA as the primary induction therapy for 17 newly diagnosed patients,