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Acute promyelocytic leukemia: Molecular genetics and pathophysiology

✍ Scribed by Elizabeth A. McGuire


Book ID
119143080
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
361 KB
Volume
14
Category
Article
ISSN
0197-1859

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The molecular genetics of acute promyelo
✍ F. Grignani; M. Fagioli; P.F. Ferrucci; M. Alcalay; P.G. Pelicci πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 English βš– 952 KB

The chromosome breakpoints of the acute promyelocytic leukemia (APL)-specific 15;17 translocation have recently been isolated. They are localized on a previously unknown gene, PML, on chromosome 15 and in the gene that encodes the alpha retinoic acid receptor (RART) on 17. The translocation, which i