Molecular genetic testing in surgical pathology

✍ Scribed by John D. Pfeifer MD PhD

• Publisher: Lippincott, Williams & Wilkins
• Year: 2006
• Tongue: English
• Leaves: 506
• Edition: 1
• Category: Library

✦ Synopsis

Written by experts from Washington University School of Medicine, this text is a thorough review of the specific molecular genetic techniques that can provide diagnostically useful molecular genetic information on tissue samples—including cytogenetics, fluorescence in situ hybridization (FISH), PCR, electrophoresis and hybridization analysis, DNA sequence analysis, and microarrays. The first part of the book describes each technique, indicates its advantages, disadvantages, capabilities, and limitations, and systematically addresses sensitivity and specificity issues. Subsequent chapters, organized by organ system, detail the specific applications of these tests in surgical pathology. More than 150 full-color and black-and-white illustrations complement the text.

✦ Table of Contents

Content: Structure and function of DNA and RNA --
DNA damage, mutations, and repair --
Cytogenetics --
Fluorescence in situ hybridization / Arie Perry --
Polymerase chain reaction --
Nucleic acid electrophoresis and hybridization --
DNA sequence analysis --
Sensitivity and specificity issues --
Microarrays / Mark A. Watson --
Clinical testing of patient specimens / Barbara A. Zehnbauer --
Tumors of soft tissue and bone --
Endocrine system --
Molecular diagnostics in hematopathology / M. Rajan Mariappan and Daniel A. Arber --
Neural tumors and neuromuscular diseases / Pang-hsien Tu, Christine E. Fuller, and Arie Perry --
Gastrointestinal tract --
Reproductive organs --
Urinary tract --
Skin --
Lung and mediastinum --
Breast --
Head and neck --
Infectious diseases --
Identity determination --
The future.