with the germline mutation of a DNA mismatch repair gene. Tumors from these Departments of Pathology and Medicine, Copatients typically exhibit microsatellite instability, which is a reflection of their lumbia University College of Physicians & Surlack of mismatch repair activity. The genetic diagno
Molecular genetic alteration and DNA ploidy in hereditary nonpolyposis colorectal cancer
β Scribed by Atsuo Tsuchiya; Tadashi Nomizu; Masamitsu Onda; Shinji Ohki; Hisayoshi Sato; Rikiya Abe
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 583 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1341-9625
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Lynch syndrome, or hereditary nonpolyposis colon cancer (HNPCC), is an autosomaldominant disease accounting for approximately 1 5 % of all colorectal cancer cases. Due to the lack of pathognomonic morphological or biomolecular markers, HNPCC has traditionally posed unique problems to clinicians and
## BACKGROUND. Cross-cultural genetic counseling was provided to an extended Navajo Indian family in which the MLHl gene mutation for hereditary nonpolyposis colorectal cancer (HNPCC) had been identified. The family had been observed by the authors since 1983 and over the years had been provided w
## Abstract Endometrial cancer is the second most common cancer in hereditary nonpolyposis colorectal cancer (HNPCC). It has often been overlooked to explore the possibility of HNPCC in endometrial cancer patients. Our study was to investigate how many HNPCC patients existed among endometrial cance