✦ LIBER ✦

Molecular genetics and hereditary cancer : Hereditary nonpolyposis colorectal carcinoma as a model

✍ Scribed by Ramon Parsons

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 102 KB
Volume: 80
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19970801)80:3+<533::aid-cncr2>3.0.co;2-a

No coin nor oath required. For personal study only.

✦ Synopsis

with the germline mutation of a DNA mismatch repair gene. Tumors from these Departments of Pathology and Medicine, Copatients typically exhibit microsatellite instability, which is a reflection of their lumbia University College of Physicians & Surlack of mismatch repair activity. The genetic diagnosis of these individuals relies geons, New York, New York.

on family history, tumor analysis for evidence of lack of mismatch repair, and, finally, mutational analysis of the mismatch repair genes themselves. Early diagnosis of germline mutations in HNPCC individuals is likely to lead to improved cancer surveillance and early tumor detection.

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