A s of 1999, it is possible to test selected subjects for carriage of germline mutations in genes responsible for familial adenomatous polyposis (FAP), 1,2 hereditary nonpolyposis colorectal cancer (HNPCC), 3,4 Peutz-Jeghers syndrome, 5 and juvenile polyposis. 6,7 These diseases are heterogeneous ph
Genetic counseling and interpretation of genetic tests in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer
✍ Scribed by Nora Wong; Dana Lasko; Rogério Rabelo; Leonard Pinsky; Philip H. Gordon; William Foulkes
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 865 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0012-3706
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## BACKGROUND. Cross-cultural genetic counseling was provided to an extended Navajo Indian family in which the MLHl gene mutation for hereditary nonpolyposis colorectal cancer (HNPCC) had been identified. The family had been observed by the authors since 1983 and over the years had been provided w
Lynch syndrome, or hereditary nonpolyposis colon cancer (HNPCC), is an autosomaldominant disease accounting for approximately 1 5 % of all colorectal cancer cases. Due to the lack of pathognomonic morphological or biomolecular markers, HNPCC has traditionally posed unique problems to clinicians and
We thank Ms. Jeanne Wenger and Ms. Linda M. Welch for secretarial assistance.