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Molecular conformation of a D,L stereoisomeric analogue of valinomycin, cyclo[-(L-Val-L-Hyi-L-Val-D-Hyi)2-(D-Val-L-Hyi-L-Val-D-Hyi)-]

✍ Scribed by D. A. Langs; P. Grochulski; W. L. Duax; V. Z. Pletnev; V. T. Ivanov

Publisher
Wiley (John Wiley & Sons)
Year
1991
Tongue
English
Weight
536 KB
Volume
31
Category
Article
ISSN
0006-3525

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✦ Synopsis

has been determined. Crystals grown from petroleum ether are orthorhombic, space group P2,2'2', with cell parameters a = 16.41 ( 1 ) , b = 18.76 ( 1 ) , c = 25.86 ( 1 ) A, and 2 = 4. The atomic coordinates for nonhydrogen atoms, except those of terminal carbons on one side chain, were refined in the anisotropic thermal motion approximation. The coordinate parameters of the H atoms were incorporated into the structure factor calculations at geometrically expected positions. Values of the standard and weighted R factors after refinement are 0.07$ and 0.083, respectively. The crystal structure of the molecule is asymmetric and adopts a conformation with four 4 -P 1 type and one 6 --t 1 type intramolecular hydrogen bonds between amide nitrogens and carbonyl oxygens. Valinomycin binds potassium more than 100 times strongly than the D,L stereoisomeric analogue, as a result of a different spatial orientation of potentially interacting carbonyl groups.

πŸ“œ SIMILAR VOLUMES

Crystal and molecular structure of the c
Crystal and molecular structure of the centrosymmetric meso-valinomycin analogueβ€”cyclo (D-Val-D-Hyi-D-Val-L-Hyi-L-Val-D-Hyi-L-Val-L-Hyi-L-Val-D-Hyi-L-Val-L-Hyi) (C60H102N6O18)
✍ V. Z. Pletnev; Yu. D. Fonarev; I. N. Tsygannik; V. T. Ivanov; S. V. Pletnev; D. πŸ“‚ Article πŸ“… 1995 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 437 KB πŸ‘ 2 views

Hyi-0-Val-t-Hyi) . 2H20 has been solved by x-ray direct methods. The crystals (grown from a mixture of octane/CH2C12) are an orthorhombic, centrosymmetric space group Pbca, cell parameters a = 11.458( 2), b = 25.613(3), c = 23.691 (3) k, Z = 4; therefore the molecule lies on a center of inversion i

The crystal and molecular structure of a
The crystal and molecular structure of a valinomycin analogue cyclo[(D-Val-L-Lac-L-Ala-D-Hyi)2 (D-Val-L-Lac-L-Val-D-Hyi)] Β· H2O (C50H82N6O18 Β· H2O)
✍ V. Z. Pletnev; S. N. Ruzeinikov; I. N. Tsigannik; V. T. Ivanov; S. V. Pletnev; D πŸ“‚ Article πŸ“… 1997 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 156 KB πŸ‘ 2 views

The crystal and molecular structure of the valinomycin analogue, cyclo [(D-Val-L-Lac-L-Ala-D-Hyi) 2 (D-Val-L-Lac-L-Val-D-Hyi)] has been solved by x-ray direct methods using the ''Shake and Bake'' procedure. The crystals, grown from a mixture of octane/CH 2 Cl 2 , belong to space group P2 1 (Z Γ… 4) w

The crystal and molecular structure of c
The crystal and molecular structure of cyclo-[-(D-Val-Hyi-Val-D-Hyi)3-] (meso-valinomycin, C60H102N6O18)
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## Synopsis The crystal structure of the valinomycin analog, cyclo-[(-D-Val-Hyi-Val-D-Hyi-)3-] (rneso-valinomycin, C ~~H I O ~N ~O ~S ) has been determined by direct x-ray diffraction procedures. The crystals are triclinic, space group Pi, number of molecules per unit cell 2 = 1, and cell paramete

The structure of [D-Hyi2, L-Hyi4]meso-va
The structure of [D-Hyi2, L-Hyi4]meso-valinomycin revealed by X-Ray analysis
✍ V. Z. Pletnev; I. Yu. Mikhailova; V. T. Ivanova; D. A. Langs; P. Grochulski; W. πŸ“‚ Article πŸ“… 1991 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 584 KB

## Abstract Direct x‐ray analysis has been used to determine the crystal structure of [D‐Hyi^2^, L‐Hyi^4^]__meso__‐valinomycin {cyclo[‐D‐Val‐D‐Hyi‐L‐Val‐L‐Hyi‐(D‐Val‐L‐Hyi‐L‐Val‐D‐Hyi)~2~‐], C~60~H~102~N~6~O~18~}, which crystallized from acetone with two solvent molecules. The crystals are trigonal

The X-ray structure of the monoclinic cr
The X-ray structure of the monoclinic crystal form of [D-Hyi2, L-Hyi4]meso-valinomycin
✍ V. Z. Pletnev; V. T. Ivanov; D. A. Langs; B. M. Burkhart; W. L. Duax πŸ“‚ Article πŸ“… 1997 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 139 KB

Both independent molecules in the crystal adopt a similar distorted bracelet structure with a sterically inaccessible, partially formed, ion-binding center that is stabilized by six 4 r 1 type H bonds. The observed conformation accounts for the inability of the molecule to complex ions. Close examin